Isatis root contains Indoxyl - beta - glucoside, Isatin, Indigo, Isatan B, Uridine, the Uracil, Hypoxanthine, Salicylic acid, Qingdainone, Daucosterol, beta Sitosterol, radix isatidis, B, c, and avermectin. Also contains plant protein, resin material, sugar, mustard glucoside, amino acids and trace elements. Include the gram-positive and negative bacteria antibacterial material. Bahamas blue root contains anthraquinones, beta sitosterol.
Water immersion to bacillus subtilis, staphylococcus aureus, eight league aureus, escherichia coli, salmonella typhi, paratyphoid a coli, shigella, enteritis bacteria have inhibition; Acetone extract has a similar effect, and effective for hemolytic streptococcus. On the bacteriostasis of type A meningococcal similar to garlic, honeysuckle.

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Vandetanib is a synthesis of aniline quinazoline compounds, for oral small molecule targets more butyric acid kinase inhibitor (TKI), at the same time in tumor cells of EGFR and VEGFR and RET tyrosine kinase, still can selectively inhibit other tyrosine kinase, and serine/threonine kinase, multiple targets joint block signaling, therefore is a kind of multi-channel tumor signal transduction inhibitors.

Vandetanib oral absorption is slow, extend the widely distributed, combined with plasma proteins, metabolic 2 chamber model. Healthy volunteers final 10 days half-life, drug metabolism in patients with more slowly than healthy volunteers, terminal has a half-life of about 20 days. Vandetanib slower, mainly through the excrement and urine, 21 days 69% cleared from the body. Eating had no obvious effect on drug metabolism.

Adverse reactions: 300 mg/d or less well tolerated, the most common side effects are diarrhea, rash, nausea, high blood pressure, anorexia, asymptomatic long QT and proteinuria. With the increase of dose, low phosphate concentration may occur, folliculitis, transaminase eleations, nonspecific intestinal obstruction, reduced platelet, congestive heart failure, deep vein thrombosis, pulmonary embolism, etc. The most common dose limiting toxicity (DLTs) is diarrhea, high blood pressure, and rash.

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Everolimus are mainly used for clinical prevention of rejection after kidney transplantation and heart transplants. Its action mechanism mainly includes the immunosuppressive effect, antitumor, antiviral effect, blood vessel protection. Often with immune inhibitors, such as ring spore element combination in order to reduce the toxicity.

Compared with sirolimus, according to the dimension of therapy of pharmacokinetic more superior.

According to the dimension of therapy by Swiss Novartis (Novartis) was first developed, such as and dispersed tablets dosage form. Trade name Certican. Listed in Sweden for the first time in 2003, has been fully occupied in 2006 the European market.

In addition to renal cell carcinoma, according to the dimension of therapy are in progress of neuroendocrine tumor, lymphoma and other cancers and tuberous sclerosis research, can be used as single agents or share with the existing cancer therapies. As the study drug, according to the dimension of effectiveness and safety of therapy has not been fully established in the field of tumor, is now in the strict control and monitoring of clinical trials. These tests are designed to better understand the potential benefits of the compounds and the corresponding risk. Because of the uncertainty of the clinical trials, and now can't ensure that according to the dimension of therapy can be used as a tumor indications of drugs are sold in the business world.

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Take the Pig Bile Powder is about 0. 1 g, precision said, adding 10% sodium hydroxide solution 5 ml, 120 ℃ heat 4 hours, put the cold, and hydrochloric acid to adjust the pH to 2 ~ 3, shake well. With ethyl acetate extract four times, each time 10 ml, the extracted liquid, dry, residual ethanol is dissolved, transfer to 10 ml volumetric flask, adding ethanol to scale, shake well, as the test solution. Other precision according to take in the phosphorus pentoxide decompression drying in the dryer for 24 hours of hyodeoxycholic acid reference substance right amount, adding ethanol made from each 1 ml solution containing 1 mg, as a reference substance solution. According to thin layer chromatography (appendix Ⅵ B) test, precision draw 1 mu l of test sample solution and reference substance solution 1 and 3 mu mu l l, intersection, respectively, in the same silica G thin layer plate, with a new configuration of isooctane ether - glacial acetic acid - n-butyl alcohol - water - the upper solution (10:5:5:3:1) as developing agent, swing, remove and dry spray with 10% ethanol solution of sulfuric acid in the 105 ℃ heating to the spot color is clear, take out, on the thin layer plate covering the same size glass plate, fixed with tape around as thin layer chromatography (TLC) (appendix Ⅵ B, thin layer scanning method) scan, wavelength: lambda s = 375 nm, lambda R = 650 nm, measuring the absorbance of the integral value and reference substance absorbance integral value, calculation, quick.

This article calculated on dry goods, including hyodeoxycholic acid (C24H40O4) shall not be less than 16. 0%.

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The fruits, usually acclimated whole, accept a pungent, anise-like acidity and balm that comes from capital oils, mostly carvone and limonene. They are acclimated as a aroma in breads, abnormally rye bread.

Caraway is aswell acclimated in desserts, liquors, casseroles, back-scratch and added foods. It is added frequently begin in European cuisine. For example, it is frequently acclimated in British caraway berry block and is aswell added to sauerkraut.In Serbia, it is frequently brindled over home-made acrid scones (pogačice s kimom). It is aswell acclimated to add acidity to cheeses such as bondost, pultost, nøkkelost and havarti. Akvavit and several liqueurs are fabricated with caraway. In Middle Eastern cuisine, caraway pudding is a accepted ambrosia during Ramadan. Aswell it is about fabricated and served in Levant breadth in winter and in the break of accepting a new baby.

The roots may be adapted as a basis vegetable like parsnips or carrots.

Additionally, leaves are sometimes consumed, either raw, dried, or cooked, as herbs, agnate to parsley.

Caraway bake-apple oil is aswell acclimated as a aroma basic in soaps, lotions, and perfumes.

Caraway aswell has a continued attitude of medical uses, primarily for abdomen complaints. Emerging and advancing analysis from Arabic bounded studies advance Carum carvi use as an endocrine action abutment agent, accurately accompanying to thyroid disorders and auto allowed ache (see Hashimoto's thyroiditis).


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